Project presentation

Low-temperature plasma wall breaking technology to achieve efficient extraction of natural pharmaceutical active ingredients

Theoretical basis: The effect of low temperature plasma wall breaking is affected by many factors, including plasma discharge power, discharge time, plasma source, and vacuum. These factors directly determine the energy level of the generated plasma, which in turn affects the breaking of chemical bonds in the molecular structure when the cell wall is bombarded, and eventually causes the cell to break. The study of these factors is the core of this technology.

Taking the ganoderma lucidum spore powder breaking technology as an example, single factor experiments and response surface experiments were performed on plasma discharge power, discharge time, plasma source and vacuum degree in the early stage of the project to obtain the optimal process conditions for plasma treatment.

Response surface and contour plots of plasma discharge time and discharge power on the total sugar content of Ganoderma lucidum

Response surface and contour plots of plasma discharge power and He pressure on total sugar content of Ganoderma lucidum

Response surface and contour plots of plasma discharge time and discharge power on the total sugar content of Ganoderma lucidum

Response surface and contour plots of plasma discharge time and discharge power on the total sugar content of Ganoderma lucidum

The main methods of traditional cell wall breaking include mechanical disruption, repeated freeze-thaw, ultrasonic disruption, microwave disruption, enzymolysis, and combinations of them. These cell disruption methods have their own characteristics and advantages, but also have their own technical defects.

Traditional technology

1) Wall breaking by mechanical crushing: Although it is simple to operate and has low technical thresholds, it has high energy consumption, long processing time, large calorific value, and large loss of raw materials and active ingredients in cells. These defects make the mechanical wall breaking method economically weak and lack competitiveness.

(2) Ultrasonic breaking method: short time, low temperature to break cells; but usually need to use ice bath cooling and intermittent ultrasound to reduce the temperature of the treatment solution. In addition, the low throughput is also an important factor limiting its large-scale application.

Innovative Technology

Low-temperature plasma wall breaking technology: high wall breaking rate, large treatment capacity, short time, low cost, and environmental protection, so it has broad application prospects.